Naheed Begum and Krishna A. Sailaja Pages 111 - 121 ( 11 )
Aim: The objective of the present research work was to formulate a sustained release Ibuprofen nanoparticles to reduce side effects and dosing frequency and to investigate the effect of various formulation variables such as stirring speed, organic: aqueous phase ratio, type and concentration of stabilizer on the preparation of optimized formulation of Ibuprofen loaded ethyl cellulose nanoparticles by nanoprecipitation method. Methodology: Ibuprofen loaded Ethyl cellulose nanoparticles were prepared by nanoprecipitation technique. The obtained nanoparticles were characterized for surface morphology, average particle size, zeta potential and evaluated for percentage yield, drug content, entrapment efficiency, drug loading and in vitro drug release. Results: The final optimized parameters were found to be 700rpm, 1:10 organic: aqueous ratio and 0.6% W/V of stabilizer (Tween-80, Tween-20 and PVA). On comparison of total 9 formulations C3 formulation prepared by using 0.6%w/v PVA as a stabilizer was found to be the best with highest entrapment efficiency (78%), greater stability (-49.8mV), with mean particle diameter of 586.9nm and it was able to sustain the release for about 9 hours. The SEM images of C3 formulation revealed the particles were of smooth surface with spherical morphology and low porosity. Conclusions: Based on the results the final optimized parameters were found to be 700rpm, 1:10 organic: aqueous ratio and 0.6%W/V of stabilizer (PVA) for the preparation of ibuprofen nanoparticles by nanoprecipitation technique.
Nanoparticles, nanoprecipitation, ibuprofen, entrapment efficiency, stabilizer, zeta potential.
Department of Pharmaceutics, RBVRR Women College of Pharmacy, Barkatpura, Hyderabad-500027, India.