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Oncotherapeutic Application of Resveratrol-based Inorganic Nanoparticles

Author(s):

Angela Perris, Sanchari Bhattacharya, Junaid Jawed and Muddasarul Hoda*   Pages 1 - 10 ( 10 )

Abstract:


Background: Potential therapeutic benefits of natural phytoconstituents and the emergence of nano-structured drug delivery systems have expanded the scope of enhanced chemotherapy with minimal adverse effects. Various in vivo and in vitro studies have revealed Resveratrol to be a potent anti-carcinogenic agent. Researchers are currently applying the concept of nano-science for enhancing the delivery of phyto-drugs like resveratrol, in order to carry the drug to the affected tissues and organs of cancer patients with much ease and efficiency.

Methods: The current review emphasizes the use of inorganic nanoparticles for enhancing the delivery and efficacy of resveratrol into otherwise inaccessible tumorigenic tissues.

Conclusion: The present review work summarizes a comprehensive update on the mechanism of actions of the resveratrol-based inorganic nanocomposite particles that are currently being studied against various cancer models. This work may be significant in laying the foundation for the future of metallic nanoparticles-based delivery and efficacy of phytochemicals in general and resveratrol in specific against non-invasive metastatic cancer.

Keywords:

Cancer, metastasis, resveratrol, inorganic nanoparticles, drug delivery, cellular uptake.

Affiliation:

Department of Microbiology, St. Xavier's College, 30 Mother Teresa Sarani Kolkata 700016, West Bengal, Guru Nanak Institute of Pharmaceutical Sciences and Technology, 157/F Nilgunj Road, Panihati, Kolkata- 700114, Department of Biotechnology, School of Life Sciences, Presidency University, Kolkata, Department of Biological Sciences, Aliah University, Kolkata-700160



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