Angela Perris, Sanchari Bhattacharya, Junaid Jawed and Muddasarul Hoda* Pages 1 - 10 ( 10 )
Background: Potential therapeutic benefits of natural phytoconstituents and the emergence of nano-structured drug delivery systems have expanded the scope of enhanced chemotherapy with minimal adverse effects. Various in vivo and in vitro studies have revealed Resveratrol to be a potent anti-carcinogenic agent. Researchers are currently applying the concept of nano-science for enhancing the delivery of phyto-drugs like resveratrol, in order to carry the drug to the affected tissues and organs of cancer patients with much ease and efficiency.
Methods: The current review emphasizes the use of inorganic nanoparticles for enhancing the delivery and efficacy of resveratrol into otherwise inaccessible tumorigenic tissues.
Conclusion: The present review work summarizes a comprehensive update on the mechanism of actions of the resveratrol-based inorganic nanocomposite particles that are currently being studied against various cancer models. This work may be significant in laying the foundation for the future of metallic nanoparticles-based delivery and efficacy of phytochemicals in general and resveratrol in specific against non-invasive metastatic cancer.
Cancer, metastasis, resveratrol, inorganic nanoparticles, drug delivery, cellular uptake.
Department of Microbiology, St. Xavier's College, 30 Mother Teresa Sarani Kolkata 700016, West Bengal, Guru Nanak Institute of Pharmaceutical Sciences and Technology, 157/F Nilgunj Road, Panihati, Kolkata- 700114, Department of Biotechnology, School of Life Sciences, Presidency University, Kolkata, Department of Biological Sciences, Aliah University, Kolkata-700160