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Formulation Development and Evaluation of Novel Vesicular Carrier for Enhancement of Bioavailability of Poorly Soluble Drug

Author(s):

Sumit Sharma*, Shailendra Bhatt and Vipin Saini   Pages 1 - 17 ( 17 )

Abstract:


Background: Niosomes are a vesicular carrier system comprised of a Nonionic surfactant bilayer surrounding an aqueous compartment. Niosomes are presumed to raise the intake of the poorly water-soluble drugs by M cells of Peyer's patches present in the intestine's lymphatic tissues, thereby avoiding the first-pass metabolism and increasing its oral bioavailability. Biodegradability, Nonimmunogenic nature, minimal side effects, low cost, good stability, and flexibility to incorporate hydrophilic and lipophilic drugs are other advantages of niosomes.

Objective: To formulate and evaluate a novel vesicular carrier system of a poorly soluble drug Lurasidone hydrochloride for the enhancement of its solubility and bioavailability

Methods: The thin-film hydration technique used to prepare Lurasidone hydrochloride loaded niosomes using different grades of nonionic surfactants like Brij, Span, and Tween. They evaluated for particle size, zeta potential, percent entrapment efficiency, in-vitro drug release, and in-vivo study.

Results: Niosomes comprised of Brij S-100 in drug: cholesterol: surfactant (1:1:1) showed particle size (1.15 ± 0.21 μm) and percent entrapment efficiency (97.02 ± 0.21%) and was selected for further studies. Various pharmacokinetic parameters like Cmax (281.27ng/ml), Tmax (5 h), and AUC (2640.197) were found to be significantly improved compared to plain drug solution.

Conclusion: The Niosomal formulation could be the promising drug delivery system for the controlled and sustained release of Lurasidone.

Keywords:

Niosomes, Vesicular carrier, Bioavailability enhancement, poorly soluble drug, Lurasidone hydrochloride.

Affiliation:

M.M College of Pharmacy ,Assistant Professor, Maharishi Markandeshwar Deemed To Be University, Mullana, Ambala,, M.M College of Pharmacy ,Associate Professor, Maharishi Markandeshwar Deemed To Be University, Mullana, Ambala,, M.M University Solan, Vice Chancellor, Himachal Pradesh



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