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Lipid and PLGA Microparticles for Sustained Delivery of Protein and Peptide Drugs

Author(s):

Chengyu Wu * and Huiling Mu   Pages 1 - 11 ( 11 )

Abstract:


Solid lipid particles have a great potential in sustained drug delivery, the lipid excipients are solid at room temperature with a slow degradation rate. Poly (D, L-lactic-co-glycolic acid) (PLGA) have been successfully clinically applied for the sustained delivery of peptide drugs. A recent study showed the advantage of hybrid PLGA-lipid microparticles (MPs) over PLGA MPs for sustained delivery of peptide drug in vivo. In this paper, we briefly present solid lipid MPs and PLGA MPs prepared by the double emulsion method and the spray drying method and discuss the effects of excipients on encapsulation efficiency of protein and peptide drugs in the MPs. The pros and cons of PLGA MPs and solid lipid MPs as carriers for sustained delivery of protein and peptide drugs are also discussed.

Keywords:

solid lipid microparticles, PLGA microparticles, hybrid polymer-lipid microparticles, protein and peptide drugs, drug delivery, sustained release

Affiliation:

Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100, Copenhagen, Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100, Copenhagen



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