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Nanoparticles and Vaccine Development

Author(s):

Mehdi kheirollahpour, Mohsen Mehrabi*, Naser Mohammadpour Dounighi*, Mohsen Mohammadi and Alireza Masoudi   Pages 1 - 16 ( 16 )

Abstract:


In spite of the progress of conventional vaccines, improvements are required due to concerns about the low immunogenicity of these vaccines, toxicity, instability, and the need for multiple administrations. To overcome mentioned problems, nanotechnology have recently been incorporated into vaccine development. Nanotechnology increasingly plays an important role in vaccine development Nanocarrier-based delivery systems offer an opportunity to increase the cellular and humoral immune responses. The use of nanoparticles in vaccine formulations allows not only enhanced immunogenicity and stability of antigen, but also targeted delivery and slow release. Over the past decade nanoscale size materials such as virus-like particles, liposomes, ISCOMs, polymeric, inorganic nanoparticles and emulsions have received attention as potential delivery vehicles for vaccine antigens which can both stabilize vaccine antigens and act as adjuvants. This advantage is attributable to the nanoscale particle size, which facilitates uptake by antigen presenting cells (APCs) then leading to efficient antigen recognition and presentation. Modifying the surfaces of nanoparticles with a different of targeting moieties permits the delivery of antigens to specific receptors on the cell surface, thereby stimulating selective and specific immune responses. This review provides an overview of recent advances in nanovaccinology.

Keywords:

Nanoparticles, Adjuvants, Vaccine delivery, Immune responses

Affiliation:

Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Department of Medical Nanotechnology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, The Persian Gulf Marine Biotechnology Research Center, the Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Department of pharmacology, School of Medicine, Shahroud University of Medical Sciences, Shahroud



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