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Bioinspired Nanocomposites: Applications in Disease Diagnosis and Treatment

[ Vol. 7 , Issue. 3 ]

Author(s):

Supriya Mishra, Shrestha Sharma, Md Noushad Javed, Faheem Hyder Pottoo*, Md Abul Barkat, Harshita, Md Sabir Alam, Md Amir and Md Sarafroz   Pages 206 - 219 ( 14 )

Abstract:


Recent advancement in the field of synthesis and application of nanomaterials provided holistic approach for both diagnosis as well as treatment of diseases. Briefly, three-dimensional scaffold and geometry of bioinspired nanocarriers modulate bulk properties of loaded drug at molecular/ atomic structures in a way to conjointly modulate pathological as well as altered metabolic states of diseases, in very predictable and desired manners at a specific site of the target. While, from the pharmacotechnical point of views, the bioinspired nanotechnology processes carriers either favor to enhance the solubility of poorly aqueous soluble drugs or enable well-controlled sustained release profiles, to reduce the frequency of drug regimen. Consequently, from biopharmaceutical point of view, these composite materials, not only minimize first pass metabolism but also significantly enhance in-vivo biodistribution, permeability, bio-adhesion and diffusivity. In lieu of the above arguments, the nano-processed materials exhibit an important role for diagnosis and treatments. In the diagnostic center, recent emergences and advancement in the tools and techniques to diagnose the unrevealed diseases with the help of instruments such as, computed tomography, magnetic resonance imaging etc; heavily depend upon nanotechnology-based materials. In this paper, a brief introduction and recent application of different types of nanomaterials in the field of tissue engineering, cancer treatment, ocular therapy, orthopedics, and wound healing as well as drug delivery system are thoroughly discussed.

Keywords:

Biomimetics, bionanocomposites, cancer therapy, drug delivery, metallic nanoparticles, tissue engineering.

Affiliation:

Department of Pharmacy, Raj Kumar Goel Institute of Technology, Abdul Kalam Technical University, Lucknow, Department of Pharmacy, School of Medical and Allied Sciences, K.R. Mangalam University, Gurgaon, Haryana, Department of Pharmaceutics, School of Pharmaceutical Education and Research SPER (Formerly, Faculty of Pharmacy), Jamia Hamdard, New- Delhi, Department of Pharmacology, College of Clinical Pharmacy, Imam Abdul Rahman Bin Faisal University, Dammam, 31441, Department of Pharmacy, School of Medical and Allied Sciences, K.R. Mangalam University, Gurgaon, Haryana, Department of Pharmacy, School of Medical and Allied Sciences, K.R. Mangalam University, Gurgaon, Haryana, Department of Pharmacy, School of Medical and Allied Sciences, K.R. Mangalam University, Gurgaon, Haryana, Department of Natural Product & Alternative Medicine, College of Clinical Pharmacy, Imam Abdul Rahman Bin Faisal University, Dammam, 31441, Department of Pharmaceutical Chemistry, College of Clinical Pharmacy, Imam Abdul Rahman Bin Faisal University, Dammam, 31441

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