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Radiosensitizing Effect of Cerium Oxide Nanoparticles on Human Leukemia Cells

[ Vol. 6 , Issue. 2 ]

Author(s):

Azadeh Montazeri, Zohreh Zal, Arash Ghasemi, Hooman Yazdannejat, Hossein Asgarian-Omran and Seyed Jalal Hosseinimehr*   Pages 111 - 115 ( 5 )

Abstract:


Background: Radiotherapy is an important protocol in the treatment of cancers, but radioresistance of cancerous cells is a challenge in cancer treatment.

Objective: The aim of this study was to evaluate the radiosensitizing effect of cerium oxide nanoparticles (CNPs) on human promyelocytic leukemia cells (HL-60). Method: HL-60 cells were treated with CNPs at different concentrations (10-100 μg/ml) and exposed to ionizing radiation (IR). The genotoxicity effects of CNPs or/and IR were assessed by micronuclei assay in HL-60 cells.

Results: It was found that CNPs increased the frequencies of micronuclei in HL-60 cells. CNPs pretreatment to irradiation significantly increased the IR-induced micronuclei incidences in HL-60 cells. The present study demonstrates CNPs to be an effective sensitizer on DNA damage induced by IR in HL-60 cells.

Conclusion: These findings suggest the potential application of CNPs as a highly effective radiosensitizer for the treatment of leukemia.

Keywords:

Cerium oxide nanoparticle, ionizing radiation, leukemia, nanoceria, radiosensitizing.

Affiliation:

Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Department of Radiology and Radiation Oncology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Department of Radiology and Radiation Oncology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari



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