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Topical Delivery of Erythromycin Through Cubosomes for Acne

[ Vol. 6 , Issue. 1 ]


Sana Khan, Poorva Jain, Sourabh Jain, Richa Jain, Saurabh Bhargava and Aakanchha Jain*   Pages 38 - 47 ( 10 )


Background: Topical delivery is an attractive route for local and systemic treatment. The novel topical application has many advantages like averting the GI-irritation, preventing the metabolism of drugs in the liver and increasing the bioavailability of the drug over the conventional dosage forms.

Objective: The aim of present work was to prepare and characterized erythromycin encapsulated cubosomes using different concentrations of glyceryl monooleate and poloxamer 407 by the emulsification method.

Methods: The prepared dispersion of cubosomes was characterized for surface morphology, particle size, entrapment efficiency and in vitro release. Further, optimized formulation was converted to cubosomal gel by incorporating carbopol 934 at different concentrations. The prepared gel was characterized for homogeneity, pH, viscosity, spreadibility, drug content and in vitro drug release study.

Results: The result of optimized cubosomes showed average particle size of 264.5±2.84nm and entrapment efficiency about 95.29±1.32 % and the pH of optimized cubosomal was found to be 6.5, viscosity 2475-8901(cp), drug content 95.29% and the spreadability was found to be 11.74 The in vitro drug release kinetics of optimized formulation was found to follow Korsmeyer peppas model having highest R2 value 0.835 and in vitro drug release of optimized erythromycin loaded cubosomal gel and plain drug gel in 24 hr was found to be 89.91±0.73 and 88.64±2.16, while in 36 hr plain drug gel and cubosomal gel showed drug release about 87.64±0.97 and 91.55±1.09, and sustained release was obtained after 24 hr in case of cubosomal gel.

Conclusion: Thus, as a whole it can be concluded that erythromycin loaded cubosomes are effective in topically delivering drug in sustained and non-invasive manner for treatment and prevention of acne.


Acne, cubosomes, emulsification, erythromycin, propionibacterium acnes, topical delivery.


Bhagyoday Tirth Pharmacy College, Sagar (M.P.), Bhagyoday Tirth Pharmacy College, Sagar (M.P.), Bhagyoday Tirth Pharmacy College, Sagar (M.P.), Centre for Scientific Research and Development, People’s University, Bhopal (M.P.), United Institute of Pharmacy, Allahabad, Bhagyoday Tirth Pharmacy College, Sagar (M.P.)

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