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Formulation and Evaluation of Novel Solid Lipid Microparticles for the Sustained Release of Ofloxacin

[ Vol. 5 , Issue. 4 ]

Author(s):

Aashima Hooda*, M. Sradhanjali and Popsy   Pages 329 - 341 ( 13 )

Abstract:


Objective: The aim of this study was to prepare solid lipid microparticles (SLM) with incorporated ofloxacin, suitable for oral delivery.

Methods: Ofloxacin-loaded SLM were prepared using stearic acid and chloroform as lipid matrix and Tween-80 as surfactant, by high shear homogenization technique and followed by lyophilization. The physiochemical characterization of SLMs were investigated by scanning electron microscopy, transmission electron microscopy, zeta potential, zone of inhibition, in-vitro study, ex-vivo study and stability study.

Results: The result demonstrated that the entrapment efficiency, particle size and zeta potential of microparticles were 86.02%, 203.7nm and -32.68mv, respectively. The in-vitro and ex-vivo studies showed sustained release of drug from formulation.

Conclusion: These results indicate that SLM might be a promising delivery system to enhance the pharmacological activity of ofloxacin.

Keywords:

High shear homogenization technique, ofloxacin, solid lipid microparticles, stearic acid, Tween-80.

Affiliation:

PDM College of Pharmacy, Sector-3A Bahadurgarh, Haryana, PDM College of Pharmacy, Sector-3A Bahadurgarh, Haryana, PDM College of Pharmacy, Sector-3A Bahadurgarh, Haryana

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