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Intranasal Drug Delivery: A Non-Invasive Approach for the Better Delivery of Neurotherapeutics

Author(s):

Umesh Gupta, Hitesh Kumar, Gaurav Mishra, Ashok Kumar Sharma, Avinash Gothwal and Prashant Kesharwani   Pages 1 - 12 ( 12 )

Abstract:


Background: The convoluted pathophysiology of brain disorders along with penetration issue of drugs to brain represents major hurdle that requires some novel therapies. The blood-brain barrier (BBB) denotes a rigid barrier for delivery of therapeutics in vivo, to overcome this barrier intranasal delivery is an excellent strategy to deliver the drug directly to brain via olfactory and trigeminal nerve pathways that originate as olfactory neuro-epithelium in the nasal cavity and terminate in brain.

Methods: Kind of therapeutics like low molecular weight drugs can be delivered to the CNS via this route. In this review we have outlined the anatomy and physiological aspect of nasal mucosa, certain hurdles, various strategies including importance of muco-adhesive polymers to increase the drug delivery and possible clinical prospects that are partly contribute in intranasal drug delivery.

Results: Exhaustive literature survey related to intranasal drug delivery system revealed the new strategy that circumvents the BBB, based on non-invasive concept for treating various CNS disorders. Numerous advantages like prompt effects, self-medication through wide-ranging devices, and the frequent as well protracted dosing are associated with this novel route.

Conclusion: Recently few reports have proved that nasal to brain drug delivery system that bypasses the BBB. This novel route associated with targeting efficiency and less exposure of therapeutic substances to non-target site. Nevertheless, this route desires much more research into the safe transferring of therapeutics to the brain. Role of muco-adhesive polymer and surface modification with specific ligands are area of interest of researcher to explore more about this.

Keywords:

Neurotherapeutics, Intranasal delivery, Blood-brain barrier, CNS, Mucoadhesive, Dosage form.

Affiliation:

The University of South Dakota – USD 414 E Clark St Vermillion, SD 5706, Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, Ajmer, Rajasthan, Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, Ajmer, Rajasthan, Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, Ajmer, Rajasthan, Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, Ajmer, Rajasthan, Department of Pharmaceutical Technology, School of Pharmacy, The International Medical University (IMU), Jalan Jalil Perkasa 19, Kuala Lumpur, 57000



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