Patricia D. Ospina and Paulo C. Zapata Pages 284 - 292 ( 9 )
Background: In the past few decades, the applications of nanotechnology to improve visual health and patient´s life quality have been improving. The nanoscience, introduced molecules of 100 nm in size offering alternatives to significantly improve the penetration on the ocular barriers and achieve better results on the delivery and biocompatibility of drugs inside the ocular globe.
Objective: To conduct a systematic review on nanotechnology using ocular pharmacology in order to improve patient’s quality life.
Method: The review was undertaken in Science Direct, Scopus, Elsevier, using the keywords: nanotechnology in ocular administration, ocular nanocarriers, and ocular nano drug products.
Results: In the recent decades, the most relevant innovation in nanotechnology is the implementation of nano drug products to treat ocular infections, glaucoma, nonsteroidal antiinflammatory drugs, diabetic retinopathy, macular degeneration associated with the age, drug delivery forms to stop neovascularization, and the repair of corneal ulcers among others.
Conclusion: New drugs incorporating nanotechnology are useful to enhance the penetration into the visual barriers and allow better effect of drugs. Multiple ocular disorders such as retinopathy, corneal neovascularization’s, and glaucoma, can be treated with nanotechnology prodrugs; which have better mechanisms of action and are less toxic for the ocular tissues. These new drugs are known as nanoengineered drug delivery systems (nDDS) and the supersaturated self-nano emulsifying drug delivery systems (S-SNEDDS). They are useful to improve the bioavailability and the control of the active principles of ophthalmic solutions which are released on the tissues and allow better penetration towards the posterior segment.
Liposomes, nano drug product, nanocarriers, nanoparticles, nano-pharmacology, ophthalmic drugs.
Universidad de los Andes, Colombia, Fundación Universitaria del Área Andina, Pereira, Colombia.