Satheesh Babu Natarajan and Prabakaran Laksmanan Pages 306 - 315 ( 10 )
The aim of this research was to formulate the ofloxacin loaded lipospheres as a drug delivery system to improve the oral bioavailability, reduce toxicity and achieve better patient compliance. The ofloxacin loaded lipospheres were formulated by melt dispersion technique using cetyl alcohol; poly vinyl alcohol (0.1%w/v) and pectin (1%w/v) act as lipid carrier, surfactant and co-surfactant respectively. The in vitro release kinetic studies were carried out for lipospheres loaded with ofloxacin and the value of R2 in Higuchi model is greater than 0.99 and release exponent (n), was found to be more than 0.5 that is Non-Fickian type. The in vitro release kinetic followed dissolution and then Korsmeyer–Peppas models. The bioavailability of ofloxacin loaded lipospheres was performed in rabbits after oral administration was studied. The plasma drug concentration was estimated by using a simple, accurate and precise high performance thin layer chromatographic technique. The pharmacokinetics studies demonstrated that the liposphere system enhance the bioavailability of ofloxacin by 2.45 fold after oral administration. Based on these results, we concluded that lipospheres might be a promising lipid based colloidal carrier system to enhance the bioavailability of ofloxacin.
Bioavailability, lipospheres, lipids, melt dispersion, ofloxacin, release kinetics, surfactants.
Karpagam University, Eachanari Post, Coimbatore, India.